Comix Zone is an interesting take on the standard beat em genre. You're sucked into a comic book, and have to fight your way out. The story isn't anything special, but it makes for a very nice presentation as your character hops around in panels.
The problem is that all the enemies seem to take forever to kill. You keep punching and they keep coming.
If you have the patience, it's a game worth getting. I'd say skip it if you're easily frustrated though.