It's a new outbreak of Dr. Mario madness! Dr. Mario's back, packing a prescription for fun. Rather than just twisting shapes to fill vacant spaces, Dr. Mario 64 will have you matching capsule-shaped pills to fight like-colored viruses. Players earn point bonuses when stringing combos together. Dr. Mario 64 comes with the original one- and two-player modes, and introduces a simultaneous four-player mode. Four players can go head-to-head, or they can pair up to pile on capsules in Team Battle. Let 'em race against time in Score Attack, target flashing viruses in Flash Mode, or test endurance in Marathon play. There's even a new story mode that pits Mario against pilferers trying to profit from his Megavitamins. It's a puzzling epidemic, and Dr. Mario's got the cure!